dgrA [2017-8-11 16:0:3]

c-di-GMP receptor protein, inhibits motility at high c-di-GMP concentrations

locus: BSU22910

pI: 7.88

mw: 24.98 kDa

protein length: 217 aa

gene length: 651 bp

function: control of MotA activity

product: c-di-GMP receptor protein

essential: no

synonyms: ypfA,jofA

Genomic Context

Gene

Coordinates: 2,397,019 → 2,397,672

The protein

[SW|Domains]

• contains a C-terminal PilZ domain [Pubmed|22821967]

[SW|Cofactors]

• c-di-GMP [Pubmed|22821967]

Effectors of protein activity

• binding of c-di-GMP stimulates the inhibitory interaction with [protein|86C729C7D5ABEE519ADC4A893940600BBB655EF1|MotA] [Pubmed|22821967]

Expression and Regulation

Operons

• genes: [gene|C194336ED96FA844FFE9FB43BE59ADC5D6DDB3BE|motI]-[gene|3459BA0CDAABC288ADF97B111F78C7EAC184840D|ypfB]-[gene|1ADB6E2C8DC82A242CFEFAD22443D14226F1BA60|cmk]-[gene|7C36409F155E4C91CEE902FE6937571BD0C50128|ypfD]-[gene|E91624382EC3DAABFB3123CDA818B4BEF745ACE6|fni]
  description: [pubmed|22383849]

• genes: [gene|C194336ED96FA844FFE9FB43BE59ADC5D6DDB3BE|motI]-[gene|3459BA0CDAABC288ADF97B111F78C7EAC184840D|ypfB]-[gene|1ADB6E2C8DC82A242CFEFAD22443D14226F1BA60|cmk]-[gene|7C36409F155E4C91CEE902FE6937571BD0C50128|ypfD]
  description: [pubmed|22383849]

categories

• [category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.2|Targets of c-di-GMP]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.5|Additional chemotaxis signal transduction and regulatory proteins]

Biological materials

Mutant

• MGNA-A419 (ypfA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/419 NBRP B. subtilis, Japan]

References

Reviews

• 25251856

Original Publications

• 23893111,22821967